Title :
Computational study of secondary structure of premature miRNA and inclusion of finite state automation
Author :
Nath, Joyshree ; Nath, Asoke
Author_Institution :
Indian Stat. Inst., Kolkata, India
Abstract :
For the past few years quite a lot of research has been done on pre-mature and mature miRNAs. Scientists show huge interest in this domain, as this domain is still not explored fully. It is believed to have better information on animal and plant structures and functions. Quite an amount of work has been done in assessing miRNA functions, mapping their expressions with genetic disorders, discovering correct miRNA targets and lots more. So in experimental or computational genomics perfect assessing of the structural and functional behavior of miRNAs correctly is a huge task. In this paper the authors have made a systematic study to get a proper secondary structure of the pre-mature miRNA and get the mature miRNA sequence corresponding to it. The similarities of the computational results with the experimental results will pave a new way towards certifying novel miRNAs using computational method. In the present paper the authors have introduced finite state automation to represent the secondary structure. The finite state automation approach will give better understanding the structural and functional behavior of miRNA.
Keywords :
RNA; biology computing; finite state machines; computational genomics; experimental genomics; finite state automation; genetic disorders; premature miRNA; secondary structure; Gold; chemicals on miRNAs; computational secondary structure; finite state automata; mature miRNA; premature miRNA; structural behavior;
Conference_Titel :
Information and Communication Technologies (WICT), 2013 Third World Congress on
Conference_Location :
Hanoi
DOI :
10.1109/WICT.2013.7113151