Cytocompatibility of Y2O3 and CeO2 containing bioactive glasses to aid spinal cord recovery

Author

Placek, L. ; Wren, A.W.

Author_Institution

Inamori Sch. of Eng., Alfred Univ.Alfred, Alfred, NY, USA

fYear

2015

fDate

17-19 April 2015

Firstpage

1

Lastpage

2

Abstract

SiO₂-SrO-Na₂O glasses containing incremental amounts of yttrium (Y) and/or cerium (Ce), previously developed and characterized, were assessed for cytocompatibility using the methyl thiazolyl tetrazolium (MTT) assay with L929-fibroblast cells and MC3T3-osteoblast cells. One-way analysis of variance (ANOVA) revealed LP-HY (78%-133% viability ) and LP-YCe (17%-194% viability) glass extracts maintained cytocompatibility at the majority of doses and time periods, in comparison with the osteoblast control cell population.

Keywords

biomedical materials; biomedical measurement; cellular biophysics; cerium compounds; colorimetry; composite materials; glass; materials preparation; neurophysiology; prosthetics; silicon compounds; sodium compounds; strontium compounds; yttrium compounds; ANOVA; CeO₂; CeO₂ containing bioactive glass; L929-fibroblast cell; LP-HY glass extract; LP-YCe glass extract; MC3T3-osteoblast cell; MTT assay; SiO₂-SrO-Na₂O; SiO₂-SrO-Na₂O glass; Y₂O₃; Y₂O₃ containing bioactive glass; cell viability; cerium content; cytocompatibility; dose; methyl thiazolyl tetrazolium assay; one-way analysis of variance; osteoblast control cell population; spinal cord recovery; time period; yttrium content; Analysis of variance; Glass; Sociology; Spinal cord; Surgery; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast

Conference_Location

Troy, NY

Print_ISBN

978-1-4799-8358-2

Type

conf

DOI

10.1109/NEBEC.2015.7117122

Filename

7117122