Characterizing the effects of metal oxide nanoparticle ingestion on intestinal function

Silicon Dioxide (SiO₂) and Titanium Dioxide (TiO₂) are engineered nanoparticles often ingested from food and food packaging. SiO₂ is a common additive, where it is used as a flow agent or to absorb extra water [1]. TiO₂ is commonly used as a pigment for foods including candy and medications, and is often found in cosmetic skin care products [2]. The effects of ingesting these materials, however, is not yet fully understood. The purpose of this study is to characterize the size and surface chemistry of 30 nm SiO₂ and TiO₂ nanoparticles following digestion and to determine how nanoparticle ingestion affects small intestinal alkaline phosphatase activity.