Multimodal imaging: Nanocrystal loaded PLA-shelled contrast agents

Author

Teraphongphom, Nutte ; Chhour, Peter ; Eisenbrey, John R. ; Naha, Pratap C. ; Witschey, Walter R. T. ; Cormode, David P. ; Wheatley, Margaret A.

Author_Institution

Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA

fYear

2015

fDate

17-19 April 2015

Firstpage

1

Lastpage

2

Abstract

Ultrasound Contrast Agents (UCA) are microencapsulated gas bubbles used to increase the overall contrast of the ultrasound (US) image. Novel multimodal polymeric UCA containing additional contrast agents that are active in multiple imaging modalities have been developed. Four platforms of loaded poly (lactic acid) (PLA) shelled UCA are presented. The first two platforms co-encapsulate aqueous or organic Quantum Dots (QD). The third platform contains magnetic iron oxide nanoparticles (MNP). The fourth platform contains gold nanoparticles (AuNP). All platforms showed that the properties of UCA are maintained as well as the properties of additional encapsulated contrast agent. This study explores the potential application for improving the screening of a subject using at least two different modalities.

Keywords

biomedical MRI; biomedical optical imaging; biomedical ultrasonics; bubbles; computerised tomography; encapsulation; gold; iron compounds; magnetic particles; materials preparation; nanocomposites; nanofabrication; nanomagnetics; nanomedicine; nanoparticles; polymers; quantum dots; Au; AuNP; FeO; MNP; UCA properties; US image contrast; aqueous quantum dot encapsulation; coencapsulation; encapsulated contrast agent properties; gas bubble microencapsulation; gold nanoparticle; loaded PLA shelled UCA platform; loaded poly(lactic acid) shelled UCA; magnetic iron oxide nanoparticle; multimodal imaging; multimodal polymeric UCA development; multiple imaging modality; nanocrystal loaded PLA-shelled contrast agent; organic QD encapsulation; patient screening; ultrasound contrast agents; Acoustics; Computed tomography; Magnetic resonance imaging; Nanocrystals; Scanning electron microscopy; Ultrasonic imaging; Computed tomography; Contrast agent; Fluorescence; MRI; Microbubble; Multimodality; Nanocrystal; Ultrasound;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference (NEBEC), 2015 41st Annual Northeast

Conference_Location

Troy, NY

Print_ISBN

978-1-4799-8358-2

Type

conf

DOI

10.1109/NEBEC.2015.7117202

Filename

7117202