Five-dimensional optoacoustic tomography for real-time whole brain neuroimaging of stimulus-evoked responses

Author

Gottschalk, Sven ; Fehm, Thomas F. ; Dean-Ben, X. Luis ; Razansky, Daniel

Author_Institution

Inst. for Biol. & Med. Imaging, Tech. Univ. of Munich, Neuherberg, Germany

fYear

2015

fDate

22-24 April 2015

Firstpage

873

Lastpage

875

Abstract

We present a technique for fully noninvasive acquisition of real-time volumetric multispectral optoacoustic data from whole mouse brain. The neuroimaging capacity of the new methodology is demonstrated here by simultaneous label-free assessment of multiple stimulus-evoked hemodynamic responses, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin.

Keywords

acoustic tomography; biomedical optical imaging; blood; brain; haemodynamics; molecular biophysics; neurophysiology; optical tomography; proteins; blood oxygenation; cerebral blood volume; deoxygenized hemoglobin; five-dimensional optoacoustic tomography; multiple stimulus-evoked hemodynamic responses; oxygenized hemoglobin; real-time volumetric multispectral optoacoustic data; real-time whole brain neuroimaging; stimulus-evoked responses; total hemoglobin; whole mouse brain; Blood; Hemodynamics; Mice; Neuroimaging; Real-time systems; Tomography; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference on

Conference_Location

Montpellier

Type

conf

DOI

10.1109/NER.2015.7146763

Filename

7146763