SAW assisted blood/plasma separation in microchannel with constriction-expansion transition

Author

Jingjing Zhang ; Xueyong Wei ; Juan Ren ; Xiangdong Xue ; Zhuangde Jiang

Author_Institution

State Key Lab. for Manuf. Syst. Eng., Xi´an Jiaotong Univ., Xi´an, China

fYear

2015

fDate

7-11 April 2015

Firstpage

86

Lastpage

89

Abstract

A surface acoustic wave (SAW) based microfluidic device for human blood plasma separation has been proposed and experimentally demonstrated. The microchannel consists of a constriction-expansion section and a bifurcation channel. The effect of constriction-expansion transition on the blood separation has been investigated with and without SAW. An acoustic power of 20.43 dBm is found enough for plasma isolation from 50× diluted human blood at a flow rate of 0.006μL/min. Higher acoustic power is required for the blood separation at higher flow rate. A diagram of combined working conditions is obtained for guiding the successful blood/plasma separation in the microfluidic chip of given design.

Keywords

bifurcation; bioMEMS; haemodynamics; lab-on-a-chip; microchannel flow; separation; surface acoustic wave devices; SAW assisted blood-plasma separation; acoustic power; bifurcation channel; constriction-expansion section; constriction-expansion transition; diluted human blood; flow rate; human blood plasma separation; microchannel flow; microfluidic chip design; plasma isolation; surface acoustic wave based microfluidic device; Bifurcation; Blood; Force; Microchannels; Plasmas; Surface acoustic waves;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems (NEMS), 2015 IEEE 10th International Conference on

Conference_Location

Xi´an

Type

conf

DOI

10.1109/NEMS.2015.7147379

Filename

7147379