Title :
SAW assisted blood/plasma separation in microchannel with constriction-expansion transition
Author :
Jingjing Zhang ; Xueyong Wei ; Juan Ren ; Xiangdong Xue ; Zhuangde Jiang
Author_Institution :
State Key Lab. for Manuf. Syst. Eng., Xi´an Jiaotong Univ., Xi´an, China
Abstract :
A surface acoustic wave (SAW) based microfluidic device for human blood plasma separation has been proposed and experimentally demonstrated. The microchannel consists of a constriction-expansion section and a bifurcation channel. The effect of constriction-expansion transition on the blood separation has been investigated with and without SAW. An acoustic power of 20.43 dBm is found enough for plasma isolation from 50× diluted human blood at a flow rate of 0.006μL/min. Higher acoustic power is required for the blood separation at higher flow rate. A diagram of combined working conditions is obtained for guiding the successful blood/plasma separation in the microfluidic chip of given design.
Keywords :
bifurcation; bioMEMS; haemodynamics; lab-on-a-chip; microchannel flow; separation; surface acoustic wave devices; SAW assisted blood-plasma separation; acoustic power; bifurcation channel; constriction-expansion section; constriction-expansion transition; diluted human blood; flow rate; human blood plasma separation; microchannel flow; microfluidic chip design; plasma isolation; surface acoustic wave based microfluidic device; Bifurcation; Blood; Force; Microchannels; Plasmas; Surface acoustic waves;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2015 IEEE 10th International Conference on
Conference_Location :
Xi´an
DOI :
10.1109/NEMS.2015.7147379
