Title :
Capsule-Type Magnetic Microrobot Actuated by an External Magnetic Field for Selective Drug Delivery in Human Blood Vessels
Author :
Kyun Choi ; Gunhee Jang ; Seungmun Jeon ; Jaekwang Nam
Author_Institution :
Dept. of Mech. Eng., Hanyang Univ., Seoul, South Korea
Abstract :
In this paper, we propose a novel capsule-type magnetic microrobot (CMM) that can navigate along a tubular environment and selectively release drugs in different target points actuated by a magnetic navigation system. The proposed CMM is a capsule-type structure with two cylindrical drug chambers that contain different drugs. It can navigate through a tubular environment by a magnetic gradient and release drugs at different positions by using uniform rotating magnetic fields. The proposed CMM was prototyped using 3-D printing technology. The operating conditions of a drug-releasing motion were determined by investigating the magnetic and friction torques within the body. Finally, we performed various experiments in a tubular environment to verify the validity of the proposed CMM.
Keywords :
bioMEMS; biomagnetism; blood vessels; drug delivery systems; drugs; friction; magnetic actuators; magnetic variables control; medical robotics; microrobots; motion control; three-dimensional printing; torque; torque control; 3D printing technology; capsule-type magnetic microrobot actuation; capsule-type structure; cylindrical drug chambers; drug-releasing motion; external magnetic field; friction torques; human blood vessels; magnetic navigation system; magnetic torques; selective drug delivery; tubular environment; uniform rotating magnetic fields; Coordinate measuring machines; Drugs; Fasteners; Magnetic flux; Navigation; Permanent magnets; Torque; Magnetic microrobot; magnetic navigation system; rotating screw motion; targeted drug delivery;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2014.2325055