Real time mechanical characterization of dna in liquid during a radiotherapy treatment and its theoretical analysis

Author

Perret, G. ; Lacornerie, T. ; Manca, F. ; Giordano, S. ; Kumemura, M. ; Lafitte, N. ; Jalabert, L. ; Lartigau, E. ; Fujii, T. ; Cleri, F. ; Fujita, H. ; Collard, D.

Author_Institution

Inst. of Ind. Sci. (IIS), LIMMS, Univ. of Tokyo, Tokyo, Japan

fYear

2015

fDate

21-25 June 2015

Firstpage

74

Lastpage

76

Abstract

We report the first real-time biomechanical measurement of DNA bundle degradation in stable condition when exposed to a therapeutic radiation beam and a theoretical model to describe DNA damages. The Silicon Nano Tweezers and their new microfluidic system endure the harsh environment of radiation beams and still retain molecular-level accuracy. This result paves the way for both fundamental and clinical studies of DNA degradation under radiation for improved tumor treatment.

Keywords

DNA; microfluidics; radiation therapy; DNA damages; DNA degradation; biomechanical measurement; microfluidic system; radiation beams; radiotherapy treatment; therapeutic radiation beam; tumor treatment; Cavity resonators; DNA; Degradation; Microfluidics; Radiation effects; Real-time systems; Silicon; DNA Damage Characterization; Microfluidic; Radiotherapy; Silicon Nanotweezers; gamma-ray irradiation;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7180864

Filename

7180864