DocumentCode
731698
Title
MEMS for single-islet electroisletogram
Author
Liu, Y. ; Shapero, A. ; Zhang, X. ; Kang, D. ; Park, J. ; Xu, L. ; Chang, K. ; Lin, H. ; Ferreri, K. ; Tai, Y.C.
Author_Institution
California Inst. of Technol., Pasadena, CA, USA
fYear
2015
fDate
21-25 June 2015
Firstpage
77
Lastpage
80
Abstract
This paper reports the first MEMS device designed for in vitro measuring of electroisletogram (EIG) of individual rat islets. Using vacuum to hold an islet in proximity to a microelectrode, strong EIG signals in millivolt range are obtained, while the noise is about 100μV pk-pk. This work proves the feasibility of using MEMS and EIG for high-throughput screening, in contrast to patch-clamp measurements, of islets for transplantation to treat diabetes.
Keywords
bioMEMS; bioelectric potentials; biomedical electrodes; biomedical measurement; diseases; microelectrodes; EIG; MEMS; diabetes; microelectrode; patch-clamp measurements; single-islet electroisletogram; transplantation; Electron tubes; Films; Gold; Microelectrodes; Micromechanical devices; Sugar; Islet; diabetes; electroisletogram (EIG); multielectrode arrays (MEAs);
fLanguage
English
Publisher
ieee
Conference_Titel
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location
Anchorage, AK
Type
conf
DOI
10.1109/TRANSDUCERS.2015.7180865
Filename
7180865
Link To Document