Title :
MEMS for single-islet electroisletogram
Author :
Liu, Y. ; Shapero, A. ; Zhang, X. ; Kang, D. ; Park, J. ; Xu, L. ; Chang, K. ; Lin, H. ; Ferreri, K. ; Tai, Y.C.
Author_Institution :
California Inst. of Technol., Pasadena, CA, USA
Abstract :
This paper reports the first MEMS device designed for in vitro measuring of electroisletogram (EIG) of individual rat islets. Using vacuum to hold an islet in proximity to a microelectrode, strong EIG signals in millivolt range are obtained, while the noise is about 100μV pk-pk. This work proves the feasibility of using MEMS and EIG for high-throughput screening, in contrast to patch-clamp measurements, of islets for transplantation to treat diabetes.
Keywords :
bioMEMS; bioelectric potentials; biomedical electrodes; biomedical measurement; diseases; microelectrodes; EIG; MEMS; diabetes; microelectrode; patch-clamp measurements; single-islet electroisletogram; transplantation; Electron tubes; Films; Gold; Microelectrodes; Micromechanical devices; Sugar; Islet; diabetes; electroisletogram (EIG); multielectrode arrays (MEAs);
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7180865
