Title :
Cocktail drug delivery chip for cancer drug screening
Author :
Ying-Ting Chen ; Ren-Guei Wu ; Chung-Shi Yang ; Fan-Gang Tseng
Author_Institution :
Eng. & Syst. Sci. Dept., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
This study introduces a combinatory assay platform that allows high-throughput but low-drug-dosage screening of five anti-cancer drugs as a cocktail for personalized cancer treatment. Photosensitive PEGDA hydrogel was employed for drug dosage definition through drop array formation and selective UV crosslinking process. The finally defined cocktail drugs in hydrogel will be directly released in parallel when combined with cell chips. This device is capable to combine 5 drugs with 1000 folds dynamic range in 30 second with low drug consumption for in-parallel cocktail screening process.
Keywords :
biomedical equipment; cancer; drug delivery systems; drugs; hydrogels; molecular biophysics; anticancer drugs; cancer drug screening; cell chips; cocktail drug delivery chip; combinatory assay platform; drop array formation; drug consumption; drug dosage definition; high-throughput screening; in-parallel cocktail screening process; low-drug-dosage screening; personalized cancer treatment; photosensitive PEGDA hydrogel; selective UV crosslinking process; Arrays; Cancer; Curing; Drug delivery; Drugs; Dynamic range; Testing; Cocktail drugs; PEGDA hydrogel; UV crosslinking; microdrplets;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181028
