Surface design for high-sensitivity micro-biosensor

To obtain high-sensitivity on biosensor for instance immunoassay, the amount of immobilized antibody should be increased and the orientation of immobilized antibody should be controlled. Moreover the decrease of non-specific protein adsorption also is requested to decrease the noise. The bio-conjugated phospholipid polymer interface with nano-sphere structure was achieved highly sensitive immunoassay, because the phospholipid polymer can reduce the non-specific protein adsorption. The function to reduce the non-specific protein adsorption was very effective to improve the sensitivity on every bioanalytical devises not only biosensor but also microchip electrophoresis.