Dual-function microelectrode array system for simultaneously monitoring electromechanical integration status of cardiomyocytes

Author

Hu, N. ; Fang, J. ; Li, H. ; Su, K. ; Wang, P.

Author_Institution

Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou, China

fYear

2015

fDate

21-25 June 2015

Firstpage

1519

Lastpage

1522

Abstract

In this study, a novel dual-functional cardiomyocyte-based biosensor system is developed based on microelectrode array (MEA). Primary neonatal Sprague-Dawley (SD) rat cardiomyocytes and MEA are employed in constructing the cardiomyocyte-based biosensor. Besides, the impedance detection function of MEA is explored to monitor the rhythmic beating of cardiomyocytes, while the extracellular potential is simultaneously recorded by MEA. Combined both functions, electric excitation and mechanical beating signals can be detected on one sensor chip. Also, dual-functional MEA system is established. Based on this electromechanical integration detection function, dual-functional cardiomyocyte-based biosensor system will be a utility platform for cellular physiological study and drug assessment.

Keywords

bioMEMS; bioelectric potentials; biomedical electrodes; biosensors; cellular biophysics; microelectrodes; microsensors; muscle; patient monitoring; cardiomyocyte-based biosensor; cardiomyocytes; cellular physiological study; drug assessment; dual-function microelectrode array system; dual-functional MEA system; dual-functional cardiomyocytebased biosensor system; electric excitation; electromechanical integration detection function; extracellular potential; impedance detection function; mechanical beating signals; primary neonatal SpragueDawley rat cardiomyocytes; rhythmic beating; simultaneously electromechanical integration status monitoring; Biomedical monitoring; Biosensors; Drugs; Extracellular; Impedance; Microelectrodes; Monitoring; Cardiomyocyte-based biosensor; dual-functional sensor system; electromechanical integration detection; microelectrode array (MEA);

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181225

Filename

7181225