Title :
Dual-function microelectrode array system for simultaneously monitoring electromechanical integration status of cardiomyocytes
Author :
Hu, N. ; Fang, J. ; Li, H. ; Su, K. ; Wang, P.
Author_Institution :
Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou, China
Abstract :
In this study, a novel dual-functional cardiomyocyte-based biosensor system is developed based on microelectrode array (MEA). Primary neonatal Sprague-Dawley (SD) rat cardiomyocytes and MEA are employed in constructing the cardiomyocyte-based biosensor. Besides, the impedance detection function of MEA is explored to monitor the rhythmic beating of cardiomyocytes, while the extracellular potential is simultaneously recorded by MEA. Combined both functions, electric excitation and mechanical beating signals can be detected on one sensor chip. Also, dual-functional MEA system is established. Based on this electromechanical integration detection function, dual-functional cardiomyocyte-based biosensor system will be a utility platform for cellular physiological study and drug assessment.
Keywords :
bioMEMS; bioelectric potentials; biomedical electrodes; biosensors; cellular biophysics; microelectrodes; microsensors; muscle; patient monitoring; cardiomyocyte-based biosensor; cardiomyocytes; cellular physiological study; drug assessment; dual-function microelectrode array system; dual-functional MEA system; dual-functional cardiomyocytebased biosensor system; electric excitation; electromechanical integration detection function; extracellular potential; impedance detection function; mechanical beating signals; primary neonatal SpragueDawley rat cardiomyocytes; rhythmic beating; simultaneously electromechanical integration status monitoring; Biomedical monitoring; Biosensors; Drugs; Extracellular; Impedance; Microelectrodes; Monitoring; Cardiomyocyte-based biosensor; dual-functional sensor system; electromechanical integration detection; microelectrode array (MEA);
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181225
