Title :
Using magnetic marked PEGDA-based cell sheets for three dimensional lobule-mimicking chip
Author :
Yu-Shih Chen ; Ling-Yi Ke ; Hsin-Hsiang Lo ; Cheng-Hsien Liu
Author_Institution :
Inst. of NanoEngineering & Microsyst., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
The formation and regeneration of tissue are the result of intricate temporal and spatial coordination of numerous individual cell fate processes. It is regulated not only by cell autonomous processes but also by extracellular microenvironmental stimuli. In this study, we propose lobule-mimicking culture chips by using magnetic-mark poly (ethylene glycol) diacrylate (PEGDA)-based cell sheets (MP cell sheets). It consists of four cell sheet chambers and one stacking chamber. MP cell sheets were formed by UV light two times. Using magnetic field to manipulate MP cell sheets moving and rotating. Finally, we had stacked MP cell sheets to achieve lobule-mimetic regeneration.
Keywords :
biomagnetism; biomedical materials; cellular biophysics; lab-on-a-chip; polymer blends; sheet materials; tissue engineering; UV light; extracellular microenvironmental stimuli; individual cell fate processes; intricate temporal coordination; lobule-mimetic regeneration; lobule-mimicking culture chips; magnetic field; magnetic marked PEGDA-based cell sheets; magnetic-mark poly(ethylene glycol) diacrylate-based cell sheets; spatial coordination; stacking chamber; three-dimensional lobule-mimicking chip; tissue formation; tissue regeneration; Computer architecture; Electrodes; Force; MIMICs; Magnetic fields; Microprocessors; Tissue engineering; dielectrophotrsis; lobule-mimicked; poly (ethylene glycol) diacrylate; three dimensional; tissue engineering;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181253
