Wireless screenning of degradation kinetics in pharmaceutical gelatin films

Author

Jiang, H. ; Ochoa, M. ; Park, J.H. ; Otte, A. ; Pinal, R. ; Ziaie, B.

Author_Institution

Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA

fYear

2015

fDate

21-25 June 2015

Firstpage

1889

Lastpage

1892

Abstract

We have developed a wireless sensing scheme for rapid screening of gelatin film physical degradation. The technique presents a new method for delineating the initial swelling (capacitive change) and subsequent dissolution (inductive change) phases. This is accomplished by incorporating super-paramagnetic nanoparticles into a gelatin film that is immobilized on top of a planar inductor. The degradation kinetics are measured wirelessly to identify the swelling and dissolution phases with sensitivities of 2313.4 kHz per absorbance unit during the first 60 minutes and 2214.2 kHz per absorbance unit from 60 minutes to 540 minutes.

Keywords

dissolving; gelatin; magnetic particles; nanoparticles; sensors; shielding; superparamagnetism; swelling; thin films; absorbance; degradation kinetics; dissolution; pharmaceutical gelatin films; physical degradation; planar inductor; super-paramagnetic nanoparticles; swelling; wireless screening; wireless sensing scheme; Degradation; Drugs; Films; Kinetic theory; Nanoparticles; Resonant frequency; Sensors; Degradation; dissolution; gelatin; magnetic nanoparticles; resonant frequency; swelling;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181319

Filename

7181319