Soft microfluidic neural probes for wireless drug delivery in freely behaving mice

Author

Jeong, J.-W. ; McCall, J.G. ; Zhang, Y. ; Huang, Y. ; Bruchas, M.R. ; Rogers, J.A.

Author_Institution

Dept. of Electr., Comput., & Energy Eng., Univ. of Colorado, Boulder, CO, USA

fYear

2015

fDate

21-25 June 2015

Firstpage

2264

Lastpage

2267

Abstract

We present ultrathin, soft microfluidic neural probes with wireless drug delivery capability that can be injected precisely in the deep brain tissue. These probes permit targeted, wireless, spatiotemporal control of pharmacological manipulation in freely behaving mice. Because of the flexible, wireless nature of this probe, it is minimally invasive and has potential for broad applications in neuroscience as well as clinical medicine.

Keywords

biological tissues; biomedical electrodes; brain; drug delivery systems; flexible electronics; microelectrodes; microfluidics; neurophysiology; wireless sensor networks; clinical medicine; deep brain tissue; flexible probe; freely behaving mice; neuroscience; soft microfluidic neural probes; wireless drug delivery; Drug delivery; Metals; Mice; Microfluidics; Probes; Reservoirs; Wireless communication; Wireless microfluidics; drug delivery; flexible neural probe; freely behaving mice; neuroscience; soft;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181413

Filename

7181413