Title :
Diode laser spectroscopy based monitoring of pharmaceutical freeze drying: Linking measurements to critical process parameters
Author :
Kessler, William J.
Author_Institution :
Phys. Sci. Inc., Andover, MA, USA
Abstract :
Freeze drying is used to produce dry solid from a solution to improve product stabilization. We have applied absorption spectroscopy to monitor water sublimation rates and determine product temperature during drying, a critical process parameter.
Keywords :
drying; freezing; measurement by laser beam; pharmaceuticals; semiconductor lasers; sublimation; water; absorption spectroscopy; critical process parameters; diode laser spectroscopy; dry solid; pharmaceutical freeze drying monitoring; product stabilization; product temperature; water sublimation rates; Absorption; Diode lasers; Fluid flow measurement; Monitoring; Spectroscopy; Temperature measurement; Temperature sensors;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2015 Conference on
Conference_Location :
San Jose, CA
