Title :
Tether-less implantable upconverting microscale light bulbs for deep brain neural stimulation and imaging
Author :
Chamanzar, Maysamreza ; Garfield, David J. ; Iafrati, Jillian ; Sohal, Vikaas ; Cohen, Bruce ; Schuck, P. James ; Maharbiz, Michel M.
Abstract :
We demonstrate the design and fabrication of implantable micro-scale light “bulbs” comprising of parylene-encapsulated upconverting lanthanide-doped nanocrystals (absorbing near-infrared and emitting blue light) for non-invasive targeted optogenetic stimulation of local neuronal ensembles.
Keywords :
bioelectric potentials; biomedical optical imaging; brain; light absorption; neurophysiology; optical design techniques; optical fabrication; patient treatment; blue light emission; deep brain neural imaging; deep brain neural stimulation; implantable upconverting microscale light bulb design; implantable upconverting microscale light bulb fabrication; near-infrared light absorption; noninvasive targeted optogenetic stimulation; parylene-encapsulated upconverting lanthanide-doped nanocrystals; Absorption; Brain; Glass; Imaging; Light sources; Mice; Nanocrystals;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2015 Conference on
Conference_Location :
San Jose, CA
