Title :
Ellipsometry-based opto-fluidic platform for characterizing 10,000 biomolecular reactions on solid supports in real time and for identifying inhibitors against protein-receptor interactions
Author_Institution :
Dept. of Phys., Univ. of California at Davis, Davis, CA, USA
Abstract :
We developed an optical detection platform based on nulling ellipsometry for simultaneously characterizing 10,000 biomolecular reactions on solid supports and for highly efficient identification of inhibitory molecules against specific protein-protein interactions from large compound libraries.
Keywords :
biochemistry; ellipsometry; molecular biophysics; proteins; biomolecular reactions; ellipsometry-based optofluidic platform; inhibitory molecules; nulling ellipsometry; optical detection platform; protein-protein interactions; protein-receptor interactions; Biomedical optical imaging; Compounds; Glass; Inhibitors; Probes; Proteins; Real-time systems;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2015 Conference on
Conference_Location :
San Jose, CA
