A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency

Author

Jun-Chau Chien ; Erh-Chia Yeh ; Lee, Luke P. ; Anwar, Mekhail ; Niknejad, Ali M.

Author_Institution

Univ. of California, Berkeley, Berkeley, CA, USA

fYear

2015

fDate

17-19 June 2015

Abstract

A near-field modulation chopping technique is implemented in an injection-locked oscillator sensor for the detection of protein conformation changes. With the addition of shielding electrodes, the signal is chopped by electronically switching the paths of the displacement sensing currents while minimizing the up-conversion of the 1/f noise. To maximize the dynamic range, feedback-around-sensor utilizing embedded varactors is applied. A 16-GHz prototype in 65-nm CMOS demonstrates the techniques lower the 1/f corner frequency from 10 to 0.25 kHz while achieving 74.5 dB of dynamic range. Bio-molecular sensing is validated with thermal-cycled bovine serum albumin (BSA) solutions at different conditions.

Keywords

1/f noise; CMOS integrated circuits; biochemistry; biological techniques; biomedical electronics; biomedical measurement; injection locked oscillators; microwave detectors; molecular biophysics; molecular configurations; proteins; prototypes; 1/f corner frequency loweting; 1/f noise; 16-GHz prototype; 65-nm CMOS; BSA solution condition variation; biomolecular sensing; displacement sensing current path switching; dynamic range maximization; electronic path switching; embedded varactor; feedback-around-sensor; frequency 16 GHz; injection-locked oscillator sensor stabilization; microwave frequency; near-field modulation chopping technique; protein conformation change detection; shielding electrode; signal chopping; size 65 nm; thermal-cycled bovine serum albumin solution; up-conversion minimization; 1f noise; Frequency modulation; Proteins; Sensitivity; Sensors; Switches;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits (VLSI Circuits), 2015 Symposium on

Conference_Location

Kyoto

Print_ISBN

978-4-86348-502-0

Type

conf

DOI

10.1109/VLSIC.2015.7231312

Filename

7231312