Title :
Modeling the Effect of Intravenous Anesthetics: A Path Toward Individualization
Author :
Silva, Margarida M. ; Medvedev, Alexander ; Wigren, Torbjorn ; Mendonca, Teresa
Abstract :
The modeling of the effect of intravenous anesthetics in the human body that accounts for the interpatient and intrapatient variability is essential not only for therapy individualization, but also for enabling the construction of reduced complexity feedback controllers. This paper reviews the path from complex pharmacokinetic/pharmacodynamic (PK/PD) models to reduced models that allow for runtime parameter estimation and provide good runtime prediction capabilities in the closed-loop CPSs delivering the anesthesia.
Keywords :
closed loop systems; drug delivery systems; feedback; parameter estimation; patient treatment; PK/PD models; anesthesia delivering; closed-loop CPS; complex pharmacokinetic/pharmacodynamic models; human body; interpatient variability; intrapatient variability; intravenous anesthetics effect modeling; reduced complexity feedback controllers; runtime parameter estimation; runtime prediction capabilities; therapy individualization; Adaptation models; Anesthesia; Drug delivery; Medical services; Predictive models; Statistics; Closed-loop control; Computer-human interaction; Drug delivery systems; Minimally parameterized models; Nonlinear modeling;
Journal_Title :
Design & Test, IEEE
DOI :
10.1109/MDAT.2015.2452904
