Industrial Application of Evolvable Block-Based Neural Network to Hypoglycemia Monitoring System

Insulin-dependent diabetes mellitus is classified as type 1 diabetes mellitus (T1DM), and it can be further classified as immune-mediated or idiopathic. It is dangerous and can result in unconsciousness, seizures, and even sudden death. The most common physiological parameters to be effected from a hypoglycemic reaction are heart rate and corrected QT interval of the electrocardiogram (ECG) signal. Considering the correlation between physiological parameters of an ECG signal and the status of hypoglycemia, a noninvasive hypoglycemia monitoring system is tested and introduced by proposing a hybrid particle-swarm-optimization-based block-based neural network (BBNN) algorithm. The proposed BBNN model offers advantages over conventional neural networks by performing the simultaneous optimization of both structure and weights. The hybrid particle swarm optimization with wavelet mutation searches for optimized structure and network parameters through particle information over a search space. All the actual data sets of 15 T1DM children were collected at the Department of Health, Government of Western Australia. Several experiments showed that the proposed BBNN performed well in terms of better sensitivity and specificity.