In recent years, the impact of chlorophyll content on the estimation of the fraction of absorbed photosynthetically active radiation (FPAR) has attracted increased attention. In this study, chlorophyll-related vegetation indices (VIs) were selected and tested for their capability in crop FPAR estimation using simulated Sentinel-2 data. These indices can be categorized into four classes: 1) the ratio indices; 2) the normalized difference indices; 3) the triangular area-based indices; and 4) the integrated indices. Two crops, wheat and corn, with distinctive canopy and leaf structure were studied. Measured FPAR and Sentinel-2 reflectance simulated from field spectral measurements were used. The results showed that VIs using the near-infrared and red-edge reflectance, including the modified Simple Ratio-2 (mSR2), the red-edge Simple Ratio (
), the Red-Edge Normalized Difference Vegetation Index (
), MERIS Terrestrial Chlorophyll Index (MTCI), and the Revised Optimized Soil-Adjusted Vegetation Index (OSAVI[705, 750]), had a strong linear correlation with FPAR, especially in the high biomass range. When the red-edge reflectance was used, the ratio indices (e.g., mSR2 and
) had a stronger correlation with crop FPAR than the normalized difference indices (e.g.,
). Sensitivity analysis showed that mSR2 had the strongest linear correlation with FPAR of the two crops across a growing season. Further analysis indicated that indices using the red-edge reflectance might be useful for developing FPAR retrieval algorithms that are independent of crop types. This suggests the potential for high resolution - nd high-quality mapping of FPAR for precision farming using the Sentinel-2 data.