Drug dosing control in clinical pharmacology

Author

Bailey, James M. ; Haddad, Wassim M.

Author_Institution

Dept. of Anesthesiology, Emory Univ., Atlanta, GA, USA

Volume

25

Issue

2

fYear

2005

fDate

4/1/2005 12:00:00 AM

Firstpage

35

Lastpage

51

Abstract

In this paper, the potential applications of control technology to clinical pharmacology are discussed, specifically the control of drug dosing. The use of closed-loop control for clinical pharmacology can significantly advance the understanding of the effects of pharmacological agents and anesthetics, as well as advance the state-of-the-art in drug delivery systems. In addition to delivering sedation to critically ill patients in an acute care environment, potential applications of closed-loop control include glucose, heart rate, and blood pressure regulation.

Keywords

adaptive control; closed loop systems; drug delivery systems; medical control systems; nonlinear control systems; robust control; clinical pharmacology; closed-loop control; drug dosing; general anesthesia; medical care; nonlinear adaptive control; robust control; Automatic control; Biomedical imaging; Collaboration; Control engineering; Control systems; Drugs; Medical control systems; Medical treatment; Pharmaceutical technology; Surgery;

fLanguage

English

Journal_Title

Control Systems, IEEE

Publisher

ieee

ISSN

1066-033X

Type

jour

DOI

10.1109/MCS.2005.1411383

Filename

1411383