DocumentCode
761003
Title
Modeling and estimation for patient controlled analgesia of chronic pain
Author
Jacobs, Oliver L R ; Liu, Yan P. ; McQuay, Henry J.
Author_Institution
Dept. of Eng. Sci., Oxford Univ., UK
Volume
42
Issue
5
fYear
1995
fDate
5/1/1995 12:00:00 AM
Firstpage
477
Lastpage
485
Abstract
An existing mathematical model of the patient and the pain in patient controlled analgesia is extended to account for the potent metabolite morphine-6β-glucuronide and to characterize chronic pain. Nominal population parameters characterizing pain and analgesic effect are tuned to make the model match observed clinical behavior. The model is used to design an on-line estimator generating state estimates which should be suitable for use in a stochastic PCA algorithm delivering a self-adjusting continuous infusion
Keywords
physiological models; chronic pain; morphine-6β-glucuronide; nominal population parameters; observed clinical behavior; on-line estimator; patient controlled analgesia; patient mathematical model; potent metabolite; self-adjusting continuous infusion; state estimates generation; stochastic PCA algorithm; Algorithm design and analysis; Feedback; Jacobian matrices; Mathematical model; Microprocessors; Pain; Principal component analysis; Safety; State estimation; Stochastic processes;
fLanguage
English
Journal_Title
Biomedical Engineering, IEEE Transactions on
Publisher
ieee
ISSN
0018-9294
Type
jour
DOI
10.1109/10.376152
Filename
376152
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