Title :
A charge-modulated FET for detection of biomolecular processes: conception, modeling, and simulation
Author :
Barbaro, Massimo ; Bonfiglio, Annalisa ; Raffo, Luigi
Author_Institution :
Dept. of Electr. & Electron. Eng., Univ. of Cagliari, Italy
Abstract :
A novel, solid-state sensor for charge detection in biomolecular processes is proposed. The device, called charge-modulated field-effect transistor, is compatible with a standard CMOS process, thus allowing fully electronic readout and large scale of integration of biosensors on a single chip. The detection mechanism is based on the field-effect modulation induced by electric charge changes related to the bioprocess. A model of the device was developed, to provide a manageable relationship between its output and geometric, design and process parameters. Extensive two- and three-dimensional simulations of the proposed structure validated the model and the working principle.
Keywords :
CMOS integrated circuits; DNA; MOSFET; biomolecular electronics; biosensors; CMFET; CMOS process; DNA detection; DNA-chip; FET; MOS transistor; biomolecular processes; biosensors; charge sensor; charge-modulated field-effect transistor sensor; electronic readout; field-effect modulation; large scale integration; solid-state sensor; Biomedical optical imaging; Biosensors; CMOS process; DNA; Electrodes; FETs; Labeling; Semiconductor device modeling; Solid modeling; Solid state circuits; Charge sensor; DNA detection; DNA-chip; field-effect transistor (FET) sensor; micro-arrays;
Journal_Title :
Electron Devices, IEEE Transactions on
DOI :
10.1109/TED.2005.860659
