Title :
Building three-dimensional ribonucleic acid structures
Author_Institution :
Dept. d´´Inf. et de Recherche Oper., Montreal Univ., Que., Canada
Abstract :
MC-Sym is an intelligent computer system that builds 3D ribonucleic acid structures from low-resolution data by combining symbolic and numerical computations. Specifically, the symbolic step generates all-atom sketches of 3D structures that nonlinear optimization methods can refine in a second step.
Keywords :
biology computing; expert systems; macromolecules; nonlinear programming; symbol manipulation; 3D ribonucleic acid structures; MC-Sym; all-atom sketches; intelligent computer system; low-resolution data; nonlinear optimization methods; numerical computations; symbolic computations; three-dimensional ribonucleic acid structures; Biochemistry; Biology computing; Buildings; Intelligent structures; Intelligent systems; Laboratories; Nuclear magnetic resonance; Optimization methods; Proteins; RNA;
Journal_Title :
Computing in Science & Engineering
DOI :
10.1109/MCISE.2003.1225860
