Quartz Crystal Microbalance Induced Bond Rupture Sensing for Medical Diagnostics

Author

van der Werff, M.J. ; Yuan, Y.J. ; Hirst, E.R. ; Xu, W.L. ; Chen, H. ; Bronlund, J.E.

Author_Institution

Ind. Res. Ltd., Crown Res. Inst., Lower Hutt

Volume

7

Issue

5

fYear

2007

fDate

5/1/2007 12:00:00 AM

Firstpage

762

Lastpage

769

Abstract

Disease detection at the point of care could be performed using quartz crystal microbalance (QCM) induced rupture of antibody-antigen bonds. An integrated digital solution for smart sensing is proposed where the QCM is driven and its resonant frequency change is captured as an indication of bond rupture. After reviewing the principle of QCM induced bond rupture, a digital transceiver system is designed and fabricated that integrates transmitter, receiver, amplification, and impedance matching. The system communicates with a PC and its functionalities are implemented in digital signal processor (DSP) software. A benchmark test using biotin and streptavidin bond is conducted and the encouraging results are given

Keywords

biosensors; digital signal processing chips; diseases; impedance matching; intelligent sensors; microbalances; patient diagnosis; quartz; transceivers; antibody-antigen bonds; biosensor; bond rupture sensing; digital signal processor software; digital transceiver system; disease detection; impedance matching; integrated digital solution; medical diagnostics; quartz crystal microbalance; smart sensing; Bonding; Communication system software; Digital signal processing; Digital signal processors; Diseases; Impedance matching; Medical diagnosis; Resonant frequency; Transceivers; Transmitters; Antibody–antigen; biosensor; bond rupture; digital transceiver; quartz crystal microbalance (QCM);

fLanguage

English

Journal_Title

Sensors Journal, IEEE

Publisher

ieee

ISSN

1530-437X

Type

jour

DOI

10.1109/JSEN.2007.894131

Filename

4154696