Title :
Brain–Silicon Interface for High-Resolution in vitro Neural Recording
Author :
Aziz, J.N.Y. ; Genov, R. ; Bardakjian, B.L. ; Derchansky, M. ; Carlen, P.L.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Toronto, Ont.
fDate :
3/1/2007 12:00:00 AM
Abstract :
A 256-channel integrated interface for simultaneous recording of distributed neural activity from acute brain slices is presented. An array of 16 times 16 Au recording electrodes are fabricated directly on the die. Each channel implements differential voltage acquisition, amplification and band-pass filtering. In-channel analog memory stores an electronic image of neural activity. A 3 mm times 4.5 mm integrated prototype fabricated in a 0.35-mum CMOS technology is experimentally validated in single-channel extracellular in vitro recordings from the hippocampus of mice and in multichannel simultaneous recordings in a controlled environment
Keywords :
CMOS analogue integrated circuits; amplification; analogue storage; band-pass filters; bioelectric potentials; brain; elemental semiconductors; microelectrodes; neurophysiology; silicon; 0.35 mum; 3 mm; 4.5 mm; Au; CMOS technology; amplification; bandpass filtering; brain-silicon interface; differential voltage acquisition; electrodes; electronic image; high-resolution in vitro neural recording; hippocampus; in-channel analog memory; integrated interface; mice; Analog memory; Band pass filters; Brain; CMOS technology; Electrodes; Filtering; Gold; In vitro; Prototypes; Voltage; Acute brain slices; integrated neural interfaces; neural amplifier; on-chip microelectrodes;
Journal_Title :
Biomedical Circuits and Systems, IEEE Transactions on
DOI :
10.1109/TBCAS.2007.893181
