Brain–Silicon Interface for High-Resolution in vitro Neural Recording

Author

Aziz, J.N.Y. ; Genov, R. ; Bardakjian, B.L. ; Derchansky, M. ; Carlen, P.L.

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Toronto, Ont.

Volume

1

Issue

1

fYear

2007

fDate

3/1/2007 12:00:00 AM

Firstpage

56

Lastpage

62

Abstract

A 256-channel integrated interface for simultaneous recording of distributed neural activity from acute brain slices is presented. An array of 16 times 16 Au recording electrodes are fabricated directly on the die. Each channel implements differential voltage acquisition, amplification and band-pass filtering. In-channel analog memory stores an electronic image of neural activity. A 3 mm times 4.5 mm integrated prototype fabricated in a 0.35-mum CMOS technology is experimentally validated in single-channel extracellular in vitro recordings from the hippocampus of mice and in multichannel simultaneous recordings in a controlled environment

Keywords

CMOS analogue integrated circuits; amplification; analogue storage; band-pass filters; bioelectric potentials; brain; elemental semiconductors; microelectrodes; neurophysiology; silicon; 0.35 mum; 3 mm; 4.5 mm; Au; CMOS technology; amplification; bandpass filtering; brain-silicon interface; differential voltage acquisition; electrodes; electronic image; high-resolution in vitro neural recording; hippocampus; in-channel analog memory; integrated interface; mice; Analog memory; Band pass filters; Brain; CMOS technology; Electrodes; Filtering; Gold; In vitro; Prototypes; Voltage; Acute brain slices; integrated neural interfaces; neural amplifier; on-chip microelectrodes;

fLanguage

English

Journal_Title

Biomedical Circuits and Systems, IEEE Transactions on

Publisher

ieee

ISSN

1932-4545

Type

jour

DOI

10.1109/TBCAS.2007.893181

Filename

4156128