Title :
Magnetic source images determined by a lead-field analysis: the unique minimum-norm least-squares estimation
Author :
Wang, Jia-Zhu ; Williamson, Samuel J. ; Kaufman, Lloyd
Author_Institution :
Neuromagnetism Lab., New York Univ., NY, USA
fDate :
7/1/1992 12:00:00 AM
Abstract :
The minimum norm least-squares approach based on lead field theory provides a unique inverse solution for a magnetic source image that is the best estimate in the least-squares sense. This has been applied to determine the source current distribution when the primary current is confined to a surface or set of surfaces. In model simulations of cortical activity of the human brain, the magnetic field pattern across the scalp is interpreted with prior knowledge of anatomy to yield a unique magnetic source image across a portion of cerebral cortex, without resort to an explicit source model.
Keywords :
biomagnetism; brain models; inverse problems; least squares approximations; cerebral cortex; cortical activity; explicit source model; human brain; inverse solution; lead-field analysis; magnetic field pattern across; magnetic source image; minimum-norm least-squares estimation; model simulations; primary current; scalp; source current distribution; Anatomy; Brain modeling; Cerebral cortex; Current distribution; Humans; Image analysis; Magnetic analysis; Magnetic confinement; Magnetic fields; Scalp; Artifacts; Electrodes; Humans; Image Enhancement; Least-Squares Analysis; Magnetoencephalography; Sensitivity and Specificity;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
