Magnetic source images determined by a lead-field analysis: the unique minimum-norm least-squares estimation

Author

Wang, Jia-Zhu ; Williamson, Samuel J. ; Kaufman, Lloyd

Author_Institution

Neuromagnetism Lab., New York Univ., NY, USA

Volume

39

Issue

7

fYear

1992

fDate

7/1/1992 12:00:00 AM

Firstpage

665

Lastpage

675

Abstract

The minimum norm least-squares approach based on lead field theory provides a unique inverse solution for a magnetic source image that is the best estimate in the least-squares sense. This has been applied to determine the source current distribution when the primary current is confined to a surface or set of surfaces. In model simulations of cortical activity of the human brain, the magnetic field pattern across the scalp is interpreted with prior knowledge of anatomy to yield a unique magnetic source image across a portion of cerebral cortex, without resort to an explicit source model.

Keywords

biomagnetism; brain models; inverse problems; least squares approximations; cerebral cortex; cortical activity; explicit source model; human brain; inverse solution; lead-field analysis; magnetic field pattern across; magnetic source image; minimum-norm least-squares estimation; model simulations; primary current; scalp; source current distribution; Anatomy; Brain modeling; Cerebral cortex; Current distribution; Humans; Image analysis; Magnetic analysis; Magnetic confinement; Magnetic fields; Scalp; Artifacts; Electrodes; Humans; Image Enhancement; Least-Squares Analysis; Magnetoencephalography; Sensitivity and Specificity;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.142641

Filename

142641