DocumentCode :
801901
Title :
A 0.18- 
m CMOS Array Sensor for Integrated Time-Resolved Fluorescence Detection
Author :
Huang, Ta-chien D. ; Sorgenfrei, Sebastian ; Gong, Ping ; Levicky, Rastislav ; Shepard, Kenneth L.
Author_Institution :
Dept. of Electr. Eng., Columbia Univ., New York, NY
Volume :
44
Issue :
5
fYear :
2009
fDate :
5/1/2009 12:00:00 AM
Firstpage :
1644
Lastpage :
1654
Abstract :
This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 times 106 photons/cm2 with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
Keywords :
CMOS image sensors; bio-optics; biological techniques; fluorescence; lab-on-a-chip; molecular biophysics; optical microscopy; CMOS array sensor; active DNA microarray; biomolecular detection; fluorescence lifetime imaging microscopy; high-frame-rate imager; integrated time-resolved fluorescence detection spectroscopy; measured impulse response; photon density; size 0.18 mum; CMOS image sensors; Detectors; Fluorescence; In vitro; In vivo; Microscopy; Optical filters; Optical imaging; Optoelectronic and photonic sensors; Sensor arrays; Biosensor; CMOS image sensor; fluorescence; microarray;
fLanguage :
English
Journal_Title :
Solid-State Circuits, IEEE Journal of
Publisher :
ieee
ISSN :
0018-9200
Type :
jour
DOI :
10.1109/JSSC.2009.2016994
Filename :
4907340
Link To Document :
