In vivo pressure estimation using subharmonic contrast microbubble signals: proof of concept

Author

Forsberg, Flemming ; Liu, Ji-Bin ; Shi, William T. ; Furuse, Junji ; Shimizu, Masafumi ; Goldberg, Barry B.

Author_Institution

Dept. of Radiol., Thomas Jefferson Univ., Philadelphia, PA, USA

Volume

52

Issue

4

fYear

2005

fDate

4/1/2005 12:00:00 AM

Firstpage

581

Lastpage

583

Abstract

Changes in ambient pressure affects the reflectivity of ultrasound contrast microbubbles leading to an excellent correlation between subharmonic signals and hydrostatic pressure. The aortas of two dogs were scanned with an experiment pulse-echo system to validate in vivo pressure estimation based on subharmonic microbubble signals. Results matched well with instantaneous pressure measurements (from 20-60 mmHg) obtained simultaneously with a pressure catheter (root mean square errors <27%).

Keywords

biomedical ultrasonics; bubbles; hydrostatics; pressure measurement; ultrasonic equipment; ultrasonic measurement; ambient pressure; aorta; hydrostatic pressure; instantaneous pressure measurements; pressure catheter; pressure estimation; pulse-echo system; reflectivity; subharmonic contrast microbubble signals; ultrasound contrast microbubbles; Bandwidth; Frequency estimation; In vivo; Pressure measurement; Pulse amplifiers; Pulse generation; Scattering; Shape; Transducers; Ultrasonic imaging; Algorithms; Animals; Aorta; Blood Pressure Determination; Contrast Media; Dogs; Echocardiography; Feasibility Studies; Ferric Compounds; Image Enhancement; Image Interpretation, Computer-Assisted; Iron; Microbubbles; Oxides; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Journal_Title

Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on

Publisher

ieee

ISSN

0885-3010

Type

jour

DOI

10.1109/TUFFC.2005.1428040

Filename

1428040