Electric field of a six-needle array electrode used in drug and DNA delivery in vivo: analytical versus numerical solution

Author

Dev, Sukhendu B. ; Dhar, Deepak ; Krassowska, Wanda

Author_Institution

Gene Delivery & Expression Sci., San Diego, CA, USA

Volume

50

Issue

11

fYear

2003

Firstpage

1296

Lastpage

1300

Abstract

We present an analytical solution for the electrical potential and field established by a six-needle array electroporation electrode, which is used in vivo for cancer treatment and DNA delivery. The analytical solution closely matches the numerical solution obtained with the finite element method: the mean error is less than 0.6 %.

Keywords

DNA; biomedical electrodes; cancer; drug delivery systems; electric fields; finite element analysis; patient treatment; DNA delivery; analytical solution; cancer treatment; electroporation therapy; finite element method; mean error; numerical solution; pulsed electric fields; six-needle array electrode; Biomedical electrodes; Cancer; DNA; Drugs; Electric potential; Finite element methods; In vivo; Needles; Neoplasms; Protocols; Computer Simulation; Connective Tissue; DNA; Drug Delivery Systems; Electrodes; Electromagnetic Fields; Electroporation; Equipment Failure Analysis; Finite Element Analysis; Gene Therapy; Models, Biological; Needles; Radiometry; Transfection;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2003.818467

Filename

1237383