DocumentCode :
809319
Title :
Effect of Lesion Morphology on Microwave Signature in 2-D Ultra-Wideband Breast Imaging
Author :
Chen, Yifan ; Gunawan, Erry ; Low, Kay Soon ; Wang, Shih-Chang ; Soh, Cheong Boon ; Putti, Thomas Choudary
Author_Institution :
Sch. of Eng., Univ. of Greenwich, Kent
Volume :
55
Issue :
8
fYear :
2008
Firstpage :
2011
Lastpage :
2021
Abstract :
This paper studies the possibility of distinguishing between benign and malignant masses by exploiting the morphology-dependent temporal and spectral characteristics of their microwave backscatter response in ultra-wideband breast cancer detection. The spiculated border profiles of 2-D breast masses are generated by modifying the baseline elliptical rings based upon the irregularity of their peripheries. Furthermore, the single- and multilayer lesion models are used to characterize a distinct mass region followed by a sharp transition to background, and a blurred mass border exhibiting a gradual transition to background, respectively. Subsequently, the complex natural resonances (CNRs) of the backscatter microwave signature can be derived from the late-time target response and reveal diagnostically useful information. The fractional sequence CLEAN algorithm is proposed to estimate the lesions´ delay intervals and identify the late-time responses. Finally, it is shown through numerical examples that the locations of dominant CNRs are dependent on the lesion morphologies, where 2-D computational breast phantoms with single and multiple lesions are investigated. The analysis is of potential use for discrimination between benign and malignant lesions, where the former usually possesses a better-defined, more compact shape as opposed to the latter.
Keywords :
biological organs; biomedical imaging; cancer; cellular biophysics; gynaecology; microwave imaging; phantoms; 2-D computational breast phantoms; 2-D ultrawideband breast imaging; baseline elliptical rings; benign lesion; breast cancer detection; complex natural resonances; fractional sequence CLEAN algorithm; late-time target response; lesion morphology; malignant lesion; microwave backscatter response; microwave signature; Backscatter; Breast cancer; Cancer detection; Delay estimation; Lesions; Microwave imaging; Morphology; Nonhomogeneous media; Resonance; Ultra wideband technology; Breast cancer detection; complex natural resonances (CNRs); lesion classification; lesion modeling; ultra-wideband (UWB) microwave imaging; Breast Neoplasms; Computer Simulation; Diagnosis, Computer-Assisted; Electromagnetic Fields; Female; Humans; Microwaves; Models, Biological; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2008.921136
Filename :
4567610
Link To Document :
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