Title :
Imaging the Distribution of Magnetic Nanoparticles With Ultrasound
Author :
Norton, S.J. ; Tuan Vo-Dinh
Author_Institution :
Fitzpatrick Inst. for Photonics, Duke Univ., Durham, NC
fDate :
5/1/2007 12:00:00 AM
Abstract :
Magnetic nanoparticles can be caused to oscillate under the influence of an incident ultrasonic wave. If the particles are momentarily aligned with a magnetizing pulse creating a macroscopic magnetization, this oscillation will result in a time-varying magnetic moment which should be detectable as an induced voltage in a nearby pickup coil. In this way, focused ultrasound can be used to map, or image, the spatial distribution of the magnetic particles after these particles have been introduced into the body. The magnetic particles could be antibody-labeled to target tumor cells or used as a cardiovascular contrast agent, among other applications. The magnitude of the induced signal is estimated for one micron particles with a Fe/tissue volume fraction of 10-6, which is about the limit of detectability for MRI superparamagnetic contrast agents consisting of single domain iron-oxide particles. One advantage of this method compared to conventional MRI is potentially greater sensitivity due to the absence of a large background signal
Keywords :
bioelectric potentials; biomagnetism; biomedical ultrasonics; cardiovascular system; cellular biophysics; electromagnetic induction; magnetic particles; magnetisation; magnetoacoustic effects; nanobiotechnology; nanoparticles; tumours; MRI superparamagnetic contrast agents; antibody labeling; cardiovascular contrast agent; induced voltage; macroscopic magnetization; magnetic nanoparticle distribution; oscillation; time-varying magnetic moment; tumor cells; ultrasound imaging; Coils; Focusing; Magnetic moments; Magnetic particles; Magnetic resonance imaging; Magnetization; Nanoparticles; Tumors; Ultrasonic imaging; Voltage; Acoustic propagation; biomedical imaging; electromagnetic induction; image reconstruction; magnetization processes; magnetoacoustic effects; nanotechnology; Algorithms; Biocompatible Materials; Computer Simulation; Contrast Media; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetics; Models, Biological; Nanoparticles; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Ultrasonography;
Journal_Title :
Medical Imaging, IEEE Transactions on
DOI :
10.1109/TMI.2007.895476