DocumentCode
831180
Title
New Bounds and Tractable Instances for the Transposition Distance
Author
Labarre, Anthony
Author_Institution
Departement de Mathematique, Univ. Libre de Bruxelles, Brussels
Volume
3
Issue
4
fYear
2006
Firstpage
380
Lastpage
394
Abstract
The problem of sorting by transpositions asks for a sequence of adjacent interval exchanges that sorts a permutation and is of the shortest possible length. The distance of the permutation is defined as the length of such a sequence. Despite the apparently intuitive nature of this problem, introduced in 1995 by Bafna and Pevzner, the complexity of both finding an optimal sequence and computing the distance remains open today. In this paper, we establish connections between two different graph representations of permutations, which allows us to compute the distance of a few nontrivial classes of permutations in linear time and space, bypassing the use of any graph structure. By showing that every permutation can be obtained from one of these classes, we prove a new tight upper bound on the transposition distance. Finally, we give improved bounds on some other families of permutations and prove formulas for computing the exact distance of other classes of permutations, again in polynomial time
Keywords
biology computing; genetics; graphs; molecular biophysics; complexity; graph representations; permutation; polynomial time; transposition distance; Approximation algorithms; Bioinformatics; Biological system modeling; Genomics; Helium; Polynomials; Sorting; Tin; Upper bound; Genome rearrangements; permutations; sorting by transpositions.; Algorithms; Chromosome Mapping; DNA Mutational Analysis; DNA Transposable Elements; Evolution, Molecular; Linkage Disequilibrium; Sequence Alignment; Sequence Analysis, DNA;
fLanguage
English
Journal_Title
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
Publisher
ieee
ISSN
1545-5963
Type
jour
DOI
10.1109/TCBB.2006.56
Filename
4015380
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