Title :
A model of the pacemaking neuron of the respiratory central pattern generator
Author :
Amini, Behrang ; Bidani, Akhil ; Zwischenberger, Joseph B. ; Clark, John W., Jr.
Author_Institution :
Dept. of Neurobiol. & Anatomy, Univ. of Texas Health Sci. Center, Houston, TX, USA
fDate :
6/1/2005 12:00:00 AM
Abstract :
We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.
Keywords :
neurophysiology; physiological models; pneumodynamics; Hodgkin-Huxley-type medullary neurons; mammalian respiratory central pattern generator; pacemaking neuron model; preBotzinger complex; Biological neural networks; Character generation; Circuits; Clamps; Modeling; Neurons; Neuroscience; Respiratory system; Temperature; Voltage; Biological system modeling; Hodgkin–Huxley models; neural networks; respiratory system; Action Potentials; Animals; Biological Clocks; Computer Simulation; Feedback; Humans; Lung; Medulla Oblongata; Models, Neurological; Nerve Net; Respiratory Mechanics; Synaptic Transmission;
Journal_Title :
Neural Systems and Rehabilitation Engineering, IEEE Transactions on
DOI :
10.1109/TNSRE.2005.847379
