Title :
Remote System for Monitoring Animal Models With Single-Metabolite Bio-Nano-Sensors
Author :
Carrara, Sandro ; Bolomey, L. ; Boero, Cristina ; Cavallini, Andrea ; Meurville, E. ; De Micheli, G. ; Jost, Tanja Rezzonico ; Proietti, M. ; Grassi, Flavia
Author_Institution :
Swiss Fed. Inst. of Technol. (EPFL), Lausanne, Switzerland
Abstract :
A novel system for remote monitoring of metabolism in an animal model is proposed in this paper. The system is obtained by integrating bio-nano-sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, a radio frequency communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate. Tests using animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted bio-nano-sensors. These tests confirm that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.
Keywords :
biosensors; electrochemical sensors; nanosensors; remote sensing; detect single-metabolites; electrochemical front-end made; monitoring animal models; off-the-shelf components; remote monitoring; remote system; single-metabolite bio-nano-sensors; Animals; Biosensors; Calibration; Electrodes; Monitoring; Sugar; Animal monitoring; SYST; body sensor node; carbon nanotubes; implantable;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2012.2231670