Title :
Magnetic stimulation of curved nerves
Author :
Rotem, A. ; Moses, E.
Author_Institution :
Weizmann Inst. of Sci., Israel
fDate :
3/1/2006 12:00:00 AM
Abstract :
Magnetic stimulation of nerves is attracting increased attention recently, as it has been found to be useful in therapy of neural disorders in humans. In an effort to explain the mechanisms of magnetic stimulation, we focus in this paper on the dependence of magnetic stimulation on neuronal morphology and in particular on the importance of curvature of axonal bundles. Using the theory of passive membrane dynamics, we predict the threshold power (the minimum stimulation power required to initiate an action potential) of specific axonal morphologies. In the experimental section, we show that magnetic stimulation of the frog sciatic nerve follows our theoretical predictions. Furthermore, the voltage length constant of the nerve can be measured based on these results alone.
Keywords :
bioelectric potentials; biomagnetism; biomembranes; cellular biophysics; neurophysiology; patient treatment; action potential; axonal bundles; curved nerves; frog sciatic nerve; magnetic stimulation; neural disorders; neuronal morphology; passive membrane dynamics; Biomembranes; Coils; Humans; Length measurement; Magnetic field measurement; Magnetic stimulation; Medical treatment; Morphology; Nerve fibers; Threshold voltage; Curvature; magnetic stimulation; nerve; threshold power; voltage length constant; Action Potentials; Animals; Computer Simulation; Differential Threshold; Electric Stimulation; Magnetics; Models, Neurological; Muscle, Skeletal; Rana ridibunda; Sciatic Nerve;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2005.869770