A 128 × 128 CMOS biosensor array for extracellular recording of neural activity

Author

Eversmann, Björn ; Jenkner, Martin ; Hofmann, Franz ; Paulus, Christian ; Brederlow, Ralf ; Holzapfl, Birgit ; Fromherz, Peter ; Merz, Matthias ; Brenner, Markus ; Schreiter, Matthias ; Gabl, Reinhard ; Plehnert, Kurt ; Steinhauser, Michael ; Eckstein, Ge

Author_Institution

Corporate Res., Infineon Technol. AG, Munich, Germany

Volume

38

Issue

12

fYear

2003

Firstpage

2306

Lastpage

2317

Abstract

Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal-oxide-semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 μm × 7.8 μm for imaging of neural activity. The related circuit and system issues as well as process aspects are discussed. A mismatch-canceling calibration circuitry with current mode signal representation is used. Results from first biological experiments are presented, which prove full functionality of the chip.

Keywords

CMOS integrated circuits; bioelectric potentials; biomedical electrodes; biomedical electronics; biomedical transducers; biosensors; neurophysiology; CMOS biosensor array; bioelectric potentials; biomedical transducers; current mode signal representation; extracellular recording; high-density sensor array; mismatch-canceling calibration circuitry; multi-electrode array; neural activity; noninvasive recording; pixel circuit; Biological tissues; Biosensors; Calibration; Circuits and systems; Extracellular; Image sensors; Neurons; Neuroscience; Pixel; Sensor arrays;

fLanguage

English

Journal_Title

Solid-State Circuits, IEEE Journal of

Publisher

ieee

ISSN

0018-9200

Type

jour

DOI

10.1109/JSSC.2003.819174

Filename

1253878