Title :
A biochip based on magnetoresistive sensors
Author :
Schotter, J. ; Kamp, P.B. ; Becker, A. ; Pühler, A. ; Brinkmann, D. ; Schepper, W. ; Brückl, H. ; Reiss, G.
Author_Institution :
Fak. fur Phys., Bielefeld Univ., Germany
fDate :
9/1/2002 12:00:00 AM
Abstract :
The signal response of Bangs Laboratories magnetic markers with a mean diameter of 0.86 μm on a spiral-shaped giant magnetoresistance sensor with a diameter of 70 μm is investigated. The data show a linear dependence of the sensor signal on the surface coverage of the magnetic markers. The detection limit is reached at a coverage of about 5%, which corresponds to about 200 markers distributed across the surface of the sensor. The corresponding molecular binding of the analyte DNA and the magnetic markers show good selectivity and sensitivity.
Keywords :
DNA; biochemistry; biomagnetism; biosensors; giant magnetoresistance; magnetoresistive devices; 0.86 micron; 70 micron; Bangs Laboratories magnetic markers; Ni80Fe20-Cu; analyte DNA molecular binding; detection limit; magnetic biosensors; magnetic marker surface coverage; magnetoresistive sensor based biochip; molecular recognition reaction; selectivity; sensitivity; sensor signal linear dependence; signal response; spiral-shaped giant magnetoresistance sensor; sputter-deposited permalloy-Cu multilayers; Biosensors; DNA; Giant magnetoresistance; Laboratories; Magnetic analysis; Magnetic sensors; Magnetic separation; Magnetoresistive devices; Probes; Tunneling magnetoresistance;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2002.802290
