Title :
Association polymers for modulated release of bioactive proteins
Author :
Raiche, Adrian T. ; Puleo, David A.
Author_Institution :
Bausch & Lomb, Rochester, NY, USA
Abstract :
The potential relevance for improving bone formation in and around tissue-engineered constructs. The objectives of this study were to investigate erosion and release of biologically active protein from CAP/PF-127 blends in an environment more representative of local growth factor delivery into a low clearance site. Within this study, effects of polymer blend ratio, sampling interval, and multilayering were examined with the ultimate goal of obtaining multiphasic release profiles over a period of several days.
Keywords :
cellular biophysics; molecular biophysics; polymers; proteins; tissue engineering; association polymers; biologically active protein; local growth factor delivery; modulated bioactive protein release; tissue-engineered constructs; Absorption; Bones; In vitro; Pistons; Polymers; Protein engineering; Spine; Temperature; Testing; Thermal degradation; Biomimetic Materials; Cellulose; Coated Materials, Biocompatible; Delayed-Action Preparations; Diffusion; Drug Delivery Systems; Drug Implants; Materials Testing; Microspheres; Muramidase; Poloxamer; Proteins; Tissue Engineering;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2003.1256270
