Title :
Genetically modified mesodermal-derived cells for bone tissue engineering
Author :
Kofron, Michelle D. ; Zhang, Jeffrey X. ; Lieberman, Jay R. ; Laurencin, Cato T.
Author_Institution :
Dept. of Orthopaedic Surg., Univ. of Virginia Health Syst., Charlottesville, VA, USA
Abstract :
Alternatives to autografts and allografts for accelerated healing of skeletal defects. This article discusses the use of cells, isolated from tissues originating from the mesodermal germ layer and genetically modified to express bone morphogenetic protein, for bone tissue engineering applications.
Keywords :
biological tissues; bone; cellular biophysics; molecular biophysics; orthopaedics; patient treatment; proteins; tissue engineering; accelerated healing; bone morphogenetic protein; bone tissue engineering; bone tissue engineering applications; genetically modified mesodermal-derived cells; mesodermal germ layer; skeletal defects; Acceleration; Biological materials; Bone tissue; Capacitive sensors; Genetic engineering; In vivo; Mechanical factors; Polymers; Skin; Stress;
Journal_Title :
Engineering in Medicine and Biology Magazine, IEEE
DOI :
10.1109/MEMB.2003.1256273
