Title :
Disposable smart lab on a chip for point-of-care clinical diagnostics
Author :
Ahn, Chong H. ; Choi, Jin-woo ; Beaucage, Gregory ; Nevin, Joseph H. ; Jeong-Bong Lee ; Puntambekar, Aniruddha ; Lee, Jae Y.
Author_Institution :
Univ. of Cincinnati, OH, USA
fDate :
1/1/2004 12:00:00 AM
Abstract :
This paper presents the development of a disposable plastic biochip incorporating smart passive microfluidics with embedded on-chip power sources and integrated biosensor array for applications in clinical diagnostics and point-of-care testing. The fully integrated disposable biochip is capable of precise volume control with smart microfluidic manipulation without costly on-chip microfluidic components. The biochip has a unique power source using on-chip pressurized air reservoirs, for microfluidic manipulation, avoiding the need for complex microfluidic pumps. In addition, the disposable plastic biochip has successfully been tested for the measurements of partial oxygen concentration, glucose, and lactate level in human blood using an integrated biosensor array. This paper presents details of the smart passive microfluidic system, the on-chip power source, and the biosensor array together with a detailed discussion of the plastic micromachining techniques used for chip fabrication. A handheld analyzer capable of multiparameter detection of clinically relevant parameters has also been developed to detect the signals from the cartridge type disposable biochip. The handheld analyzer developed in this work is currently the smallest analyzer capable of multiparameter detection for point-of-care testing.
Keywords :
amperometric sensors; biochemistry; biocontrol; biomedical equipment; biomedical measurement; biosensors; injection moulding; intelligent actuators; microfluidics; micromachining; micropumps; microsensors; microvalves; patient diagnosis; plasma materials processing; rapid thermal processing; amperometric detection; biochemical analysis; clinical diagnostics; disposable biochip; disposable plastic biochip; embedded on-chip power sources; glucose; handheld analyzer; human blood; injection molding; integrated biosensor array; lab on chip; lactate level; microfluidic manipulation; multiparameter detection; on-chip pressurized air reservoirs; partial oxygen concentration; plasma processing; plastic micromachining; point-of-care testing; precise volume control; rapid thermal process; replaceable mold disk technique; smart passive microfluidics; thermoplastic fusion bonding; Biosensors; Blood; Humans; Microfluidics; Plastics; Reservoirs; Semiconductor device measurement; Sugar; System-on-a-chip; Testing;
Journal_Title :
Proceedings of the IEEE
DOI :
10.1109/JPROC.2003.820548