Engineering Water-Dispersible FePt Nanoparticles for Biomedical Applications

Author

Chiang, Po-Chieh ; Hung, Dung-Shing ; Wang, Jeng-Wen ; Ho, Chih-Sung ; Yao, Yeong-Der

Author_Institution

Inst. of Phys., Acad. Sinica, Taipei

Volume

43

Issue

6

fYear

2007

fDate

6/1/2007 12:00:00 AM

Firstpage

2445

Lastpage

2447

Abstract

We reported the synthesis and characterization of water-based FePt nanoparticles for biomedical applications. The superparamagnetic and hydrophilic FePt nanoparticles were synthesized by phase transfer method and the particles size were just only 2-4 nm. The functional FePt nanoparticles through ligand exchanging were achieved to bind the specific biomolecules. The streptavidin-biotin binding pair was used to demonstrate that water-based FePt nanoparticles could be further functionalized to provide a biotin moiety for specific interaction with streptavidin protein.

Keywords

biochemistry; biomagnetism; iron alloys; magnetic particles; molecular biophysics; nanobiotechnology; nanoparticles; particle size; platinum alloys; proteins; superparamagnetism; 2 to 4 nm; FePt; biomedical applications; biomolecules; hydrophilic nanoparticles; ligand exchanging; particle size; phase transfer method; protein; streptavidin-biotin binding; superparamagnetic nanoparticles; water-dispersible FePt nanoparticles; Biological materials; Biomedical engineering; Biomedical materials; Chemicals; Magnetosphere; Molecular biophysics; Nanoparticles; Proteins; Saturation magnetization; Surface topography; Biomedical applications; FePt nanoparticles; phase transfer method; surface modification;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2007.894341

Filename

4202673