3D focusing of nanoparticles in microfluidic channels

Author

Morgan, H. ; Holmes, D. ; Green, N.G.

Author_Institution

Dept. of Electron. & Electr. Eng., Univ. of Glasgow, UK

Volume

150

Issue

2

fYear

2003

Firstpage

76

Lastpage

81

Abstract

Dynamic focusing of particles can be used to centre particles in a fluid stream, ensuring the passage of the particles through a specified detection volume. This paper describes a method for focusing nanoparticles using dielectrophoresis. The method differs from other focusing methods in that it manipulates the particles and not the fluid. Experimental focusing is demonstrated for a range of different particle types, and discussed in terms of the operational limits of the device. Dynamic numerical simulations of the particle motion in the device are presented and compared with the experimental results. The potential of the device for nanoparticle control and manipulation in microfluidic chips is discussed.

Keywords

Brownian motion; biological techniques; cellular biophysics; channel flow; electrohydrodynamics; electrophoresis; focusing; microfluidics; nanoparticles; two-phase flow; Brownian dynamics; detection volume; dielectrophoresis; dynamic focusing; dynamic numerical simulations; flow cytometer; fluid stream; microfluidic channels; microfluidic chips; nanoparticle 3D focusing; nanoparticle control; nanoparticle manipulation; operational limits; particle motion; particle types; rectangular channel;

fLanguage

English

Journal_Title

Nanobiotechnology, IEE Proceedings -

Publisher

iet

ISSN

1478-1581

Type

jour

DOI

10.1049/ip-nbt:20031090

Filename

1260180