Preparation, Characterization and in vitro Toxicity Test of Magnetic Nanoparticle-Based Drug Delivery System to Hyperthermia of Biological Tissues

Author

Simioni, Andreza Ribeiro ; Primo, Fernando Lucas ; Rodrigues, Marcilene Machado Andrade ; Lacava, Zulmira Guerrero Marques ; Morais, Paulo Cesar ; Tedesco, Antonio Claudio

Author_Institution

Departamento de Quimica, Sao Paulo Univ.

Volume

43

Issue

6

fYear

2007

fDate

6/1/2007 12:00:00 AM

Firstpage

2459

Lastpage

2461

Abstract

The goals of this study were first to prepare and second to test albumin-based beads containing maghemite nanoparticles dispersed on them. Incorporation of maghemite nanoparticles in the albumin-based template, allowing full control of the magnetic content, was accomplished by adding ionic magnetic fluid to the albumin suspension, following heat denaturation. The material evaluation was performed using Zeta potential measurements and scanning electron microscopy from one side and by investigating the cell activity on the other hand.

Keywords

biological tissues; biomagnetism; biomedical materials; cellular biophysics; drug delivery systems; electrokinetic effects; heat treatment; hyperthermia; iron compounds; magnetic fluids; magnetic particles; nanobiotechnology; nanoparticles; scanning electron microscopy; Fe₂O₃; albumin-based beads; biological tissues; cell activity; drug delivery system; heat denaturation; hyperthermia; ionic magnetic fluid; maghemite; magnetic nanoparticle; scanning electron microscopy; toxicity; zeta potential; Biological tissues; Drug delivery; Hyperthermia; In vitro; Magnetic levitation; Magnetic liquids; Nanobioscience; Nanoparticles; Scanning electron microscopy; Stability; AC magnetic field; hyperthermia; magnetic fluid; magnetic nanoparticle;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2007.894126

Filename

4202916