DocumentCode :
86730
Title :
Reducing Risks in Type 1 Diabetes Using 
Control
Author :
Colmegna, Patricio ; Sanchez Peña, Ricardo S. ; Gondhalekar, Ravi ; Dassau, Eyal ; Doyle, Francis J.
Author_Institution :
Centro de Sist. y Control, Inst. Tecnol. de Buenos Aires, Buenos Aires, Argentina
Volume :
61
Issue :
12
fYear :
2014
fDate :
Dec. 2014
Firstpage :
2939
Lastpage :
2947
Abstract :
A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
Keywords :
diseases; feedback; medical control systems; patient diagnosis; H∞ robust controller; UVA-Padova metabolic simulator; glucose level prediction; hyperglycemia risk reduction; insulin feedback loop; postprandial hypoglycemia risk reduction; safety mechanism; type 1 diabetes mellitus; Diabetes; H infinity control; Insulin; Prediction algorithms; Robust control; H??? control; Type??1 diabetes; hyperglycemia; hypoglycemia;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2014.2336772
Filename :
6851161
Link To Document :
