Title :
Fibre-optic interferometric immuno-sensor using long period grating
Author :
Kim, D.W. ; Zhang, Y. ; Cooper, K.L. ; Wang, A.
Author_Institution :
Bradley Dept. of Electr. & Comput. Eng., Virginia Polytech. Inst. & State Univ., Blacksburg, VA, USA
fDate :
3/16/2006 12:00:00 AM
Abstract :
A species-specific biosensor is presented based on the combined use of a reflection mode long period fibre grating with nanoscale self-assembly. Self-assembled polyelectrolyte layers and the immobilisation of immunoglobulin G (IgG) were used for sensor fabrication. The sensor´s fringe position shift induced by specific antigen-antibody binding has been observed, and non-specific binding was minimised with binding block. The results show the feasibility of the sensor for various bio/chemical applications.
Keywords :
biosensors; diffraction gratings; fibre optic sensors; light interferometry; nanotechnology; self-assembly; antigen-antibody binding; binding block; fibre-optic interferometric immuno-sensor; fringe position shift; immunoglobulin G; nanoscale self-assembly; nonspecific binding; reflection mode long period fibre grating; self-assembled poly electrolyte layers; sensor fabrication; species-specific biosensor;
Journal_Title :
Electronics Letters
DOI :
10.1049/el:20060040
