Title :
Surface Plasmon Resonance Biosensor Incorporated in a Michelson Interferometer WithEnhanced Sensitivity
Author :
Yuan, Wu ; Ho, H.P. ; Wong, C.L. ; Kong, S.K. ; Lin, Chinlon
Author_Institution :
Dept. of Electron. Eng., Chinese Univ. of Hong Kong, Shatin
Abstract :
A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer
Keywords :
Mach-Zehnder interferometers; Michelson interferometers; biosensors; sensitivity; surface plasmon resonance; Mach-Zehnder interferometer; Michelson interferometer; antibody-antigen binding reactions; differential phase interrogation; intrinsic resolution enhancement; optical beam traverses; saltwater mixtures; sensitivity enhancement; surface plasmon resonance biosensor; Biomedical optical imaging; Biosensors; Optical films; Optical interferometry; Optical refraction; Optical sensors; Optical variables control; Plasmons; Refractive index; Resonance; Biosensor; interferometry; phase interrogation; surface plasmon resonance;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2006.884982
