Title :
Carbon nanotube network-based biomolecule detection
Author :
Atashbar, Massood Z. ; Bejcek, Bruce E. ; Singamaneni, Srikanth
Author_Institution :
Electr. & Comput. Eng. Dept., Western Michigan Univ., Kalamazoo, MI
fDate :
6/1/2006 12:00:00 AM
Abstract :
In this paper, we describe a single-wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules like Streptavidin and IgG. SWNTs have been employed for two types of sensing mechanisms. First, the changes in the electrical conductance of the carbon nanotube (CNT) matrix on noncovalent binding of the biomolecules to the side walls of the CNT and, second, quantification of mass uptake of the matrix on biomolecule incubation are presented. Both sensing mechanisms exhibited consistent and highly sensitive responses. Biomolecular immobilization on the CNT surface was monitored by atomic force microscopy
Keywords :
atomic force microscopy; biosensors; carbon nanotubes; molecular biophysics; CNT surface; IgG; Streptavidin; atomic force microscopy; biological sensor; biomolecular immobilization; biomolecule detection; biomolecule incubation; biomolecules detection; carbon nanotube network; electrical conductance; noncovalent binding; quartz crystal microbalance; single-wall carbon nanotube; Acoustic signal detection; Atomic force microscopy; Atomic measurements; Biosensors; Carbon nanotubes; Face detection; Glass; Molecular biophysics; Nanobioscience; Substrates; Atomic force microscopy (AFM); carbon nanotube (CNT); quartz crystal microbalance (QCM);
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2006.874491
