Carbon nanotube network-based biomolecule detection

Author

Atashbar, Massood Z. ; Bejcek, Bruce E. ; Singamaneni, Srikanth

Author_Institution

Electr. & Comput. Eng. Dept., Western Michigan Univ., Kalamazoo, MI

Volume

6

Issue

3

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

524

Lastpage

528

Abstract

In this paper, we describe a single-wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules like Streptavidin and IgG. SWNTs have been employed for two types of sensing mechanisms. First, the changes in the electrical conductance of the carbon nanotube (CNT) matrix on noncovalent binding of the biomolecules to the side walls of the CNT and, second, quantification of mass uptake of the matrix on biomolecule incubation are presented. Both sensing mechanisms exhibited consistent and highly sensitive responses. Biomolecular immobilization on the CNT surface was monitored by atomic force microscopy

Keywords

atomic force microscopy; biosensors; carbon nanotubes; molecular biophysics; CNT surface; IgG; Streptavidin; atomic force microscopy; biological sensor; biomolecular immobilization; biomolecule detection; biomolecule incubation; biomolecules detection; carbon nanotube network; electrical conductance; noncovalent binding; quartz crystal microbalance; single-wall carbon nanotube; Acoustic signal detection; Atomic force microscopy; Atomic measurements; Biosensors; Carbon nanotubes; Face detection; Glass; Molecular biophysics; Nanobioscience; Substrates; Atomic force microscopy (AFM); carbon nanotube (CNT); quartz crystal microbalance (QCM);

fLanguage

English

Journal_Title

Sensors Journal, IEEE

Publisher

ieee

ISSN

1530-437X

Type

jour

DOI

10.1109/JSEN.2006.874491

Filename

1634400